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doi: 10.1038/nrneph.2010.58 65 SkovJDejgaardAFrokiaerJHolstJJJonassenTRittigSet al

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These include people who have had organ transplants, and those who are on immuno-suppressive therapies

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Strategies include blocking immunosuppressive ligands such as GD3 ganglioside, engineering chimeric antigen receptor (CAR) T cells to target senescence-specific surface markers like urokinase-type plasminogen activator receptor (uPAR), and exploiting metabolic vulnerabilities (e.g., glutaminolysis and ferroptosis) to sensitize SnCs to immune-mediated clearance